A new study suggests that SARS-CoV-2 like many other viruses can cross the blood-brain barrier. The spike protein of the virus dictates which cell the virus can enter. The binding proteins like the spike proteins can themselves cause damage as they detach from the virus and can cause inflammation. The spike protein likely causes the brain to release cytokines and inflammatory products leading to a cytokine storm.
The infected person is left with brain fog, fatigue, and other cognitive issues. This also could explain many of the complications of COVID-19. The researchers state that COVID-19 infection is known to cause trouble in breathing due to infection in the lungs but an additional explanation could be that the virus enters the respiratory centers of the brain and causes problems. The researchers in their experiment observed that transport of the spike protein in the olfactory bulb and kidney of males is faster as compared to females.
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