A recent study by researchers from Shenzhen Third People’s Hospital, China investigated how resveratrol, a phenolic plant compound, can modulate the replication of SARS-CoV-2 in Vero cells. Resveratrol was chosen as it has proven efficacy against inhibiting replication of several viruses, including dengue virus, influenza virus, Zika virus, and MERS-CoV (a beta coronavirus). Immunofluorescence assay and qRT-PCR were used to check the effect of resveratrol on SARS-CoV-2 infected cells.
The results revealed that resveratrol when applied before infection, was capable of inhibiting the viral replication only by 20%. Reservatrol caused a 98% reduction after infection. These findings point out that resveratrol might be more efficacious in the presence of the virus. A SIRT1 activator and an inhibitor- Sirtinol were used to investigate whether resveratrol inhibits SARS-CoV-2 replication by modulating the SIRT1 signaling pathway. Sirtino-mediated inhibition of SIRT1 signaling resulted in induction in viral replication. These findings suggest that resveratrol activated SIRT1 signaling, which may be responsible for inhibiting viral replication.
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