Polyphenols in Diet could Reduce COVID-19 Severity

WHO has informed that COVID19 is a global pandemic. There are many risk factors such as a weakened immune system, comorbidities, and age-related to COVID19. In COVID19 patients, ARDS (Acute Respiratory Distress Syndrome) is responsible for 86% of death associated with SARS-Co-V-2 infection. The pathogenesis behind SARS-Co-V-2 infection has resulted in cytokine response which attracts inflammatory cells like neutrophils and monocytes resulting in inflammatory injury in the lungs.

Cellular senescence with old age is another factor that secretes a high level of inflammatory proteins with age-related dysfunction. The dysregulation of the immune system is another important source of chronic inflammation in COVID19 infected patients. Disturbance of the inflammatory homeostasis in elderly COVID19 patients has also resulted in higher secretion of cytokine storm and this results in ARDS and higher mortality risk.

Another important factor Cytokine Storm Syndrome is a systemic inflammatory response that leads to fever, lymphadenopathy and if left untreated may lead to multiple organ failure and death. Polyphenols are dietary components that help prevent inflammatory comorbidities. They are a category of compounds naturally found in foods like herbs, fruits, vegetables, wine, dark chocolate, and tea. Past studies have shown that polyphenols can help manage blood pressure levels and keep the blood vessels healthy and flexible. Apart from blood sugar and blood pressure, polyphenols can reduce chronic inflammation.

The current study shows that since polyphenols reduce inflammation, they could help combat COVID-19. Polyphenols might help protect the body from the harmful effects of the disease. Plant-derived polyphenols have been shown to effectively inhibit the RNA virus. Consumption of a diet rich in polyphenols which is rich in antioxidant properties helps with controlling obesity and age-related inflammation.

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Ref Link: https://www.frontiersin.org/articles/10.3389/fphys.2020.612268/full