Researchers in the UK have demonstrated the efficacy of Pfizer-BioNTech and AstraZeneca vaccines against SARS-CoV-2 preventing death among older individuals. The analysis of more than 48,000 individuals, aged 70 years and older, found that COVID-19 cases who had been vaccinated with one dose of Pfizer-BioNTech’s BNT162b2 vaccine were at a 44% reduced risk of death, compared with unvaccinated individuals, while those vaccinated with one dose of AstraZeneca’s ChAdOx1 vaccine were at a 55% reduced risk.
Among individuals aged 80 years and older who had at least 28 days of follow-up data available, 16.1% of unvaccinated individuals died, compared with 9.2% among those vaccinated with one dose of BNT162b2, 11.3% of those vaccinated with one dose of ChAdOx1, and 4.7% of those vaccinated with two doses of BNT162b2. Among those aged 70-79 years with at least 28 days of follow-up data, 4.0% of unvaccinated individuals died, compared with 2.7% of those who received one dose of BNT162b2, 2.1% of those vaccinated with one dose of ChAdOx1, and 0.0% of those vaccinated with two doses of BNT162b. In the elderly aged above 80 years, it was found that the first dose and second dose of BNT162b2 were 80% and 97% effective at preventing mortality respectively.
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