Interferons Improve SARS-CoV-2 Viral Clearance

Research published in the journal Frontiers in Immunology revealed that interferons (IFN)may significantly improve virus clearance and reduce levels of inflammatory proteins in COVID-19 patients. The study included a cohort of 77 individuals with confirmed COVID-19. The cases were classified as moderate cases. The patients were treated with IFN-α2b plus ARB, and viral clearance was determined for each group. The study revealed a significantly different rate of viral clearance for each treatment. IFN-α2b treatment accelerated viral clearance by approximately 7 days.

Treatment with IFN-α2b, whether alone or in combination with ARB, accelerated viral clearance when compared to ARB treatment alone. The  IFN-α2b treatment significantly reduced the duration of detectable virus in the upper respiratory tract. The IFN treatment also significantly reduced circulating levels of CRP and IL-6. The influence of age, co-morbidities, and sex did not negate the effects of IFN treatment on viral clearance time. 

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