Horse-Derived Antibodies may Promote Immunity against COVID-19

The number of COVID-19 cases around the world is increasing. With vaccines now available the rate of its deployment is lagging behind the rate of viral spread and mutations. Researchers from India have demonstrated that horses inoculated with an inactivated dosage of SARS-CoV-2 produce large amounts of string antibodies that can neutralize multiple variants. The study is published on a pre-print server.

The team of researchers had been investigating alternative solutions to treat COVID-19. Large animals like horses can produce antibodies in large quantities. Several horses were inoculated with inactivated Indian SARS-CoV-2 cultures mixed with Freund’s complete adjuvant. Plasma samples were taken from the immunized horses and then tested for antibody response. The researchers found that the extracted antibodies were effective at neutralizing both the ancestral and deviant strains of COVID-19.

This news is especially promising as the antibodies can be sourced from the horses after less than two months from initial inoculation with the inactivated virus and can be sourced in large quantities. Additionally, the antibodies can penetrate deeper into organs and tissues due to their smaller size and lesser cellular affinity, only adding to their already beneficial properties. This research comes out after a series of trials already conducted on the applicability of horse antibodies to SARS-CoV-2. It further highlights the easy and inexpensive accessibility of these types of immunization programs.

Ref Link:

https://www.biorxiv.org/content/10.1101/2021.03.09.434030v1

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