Researchers from the USA have reported that neuropsychological symptoms are common amongst critically ill patients with COVID-19 who were hospitalized. Delirium is amongst the most common symptom. It had been reported in 65-80% of patients who needed ICU hospitalization. The researchers studied several contributing factors such as vascular events in the brain, associated inflammation, etc. In a retrospective study of critically ill COVID-19 patients’ interviews were conducted to collect data for neurological deficits. The delirium incidence was 72%. The median duration of delirium was 10 days.
New antidepressant use was seen commonly among those with delirium compared to those without delirium. Length of ICU stay, hospital stay and need for mechanical ventilation lengthened the duration of delirium in patients. Around 23% of patients had cognitive impairment after discharge. Around 12% of delirium patients developed depression after discharge. Delirium patients had elevated inflammatory markers such as CRP, D-dimer, LDH, and WBCs. The researchers state that delirium is a serious and common complication seen among those with severe COVID-19.
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