COVID-19 Related Hyperinflammatory Shock in Children

Most cases of COVID-19 have occurred in adults and scientists thought that it wouldn’t appear in kids or they would have an asymptotic approach. But a recent study published preprint medRxiv in July 2020 brings to light clusters of a new hyperinflammatory condition seen among children living in areas with epidemic disease. The study deals with the disease process and the contribution of immunity to the clinical features. The condition initially manifested with rash, fever, conjunctivitis, mucocutaneous rash, and cardiac complications which were diagnosed as Kawasaki Disease (KD) but distinct symptoms unrelated to KD were seen such as shock, gastrointestinal involvement, and coagulation abnormalities. The condition was recognized as a new disease, called multisystem inflammatory syndrome in children (MIS-C), also called pediatric inflammatory multisystem syndrome (PIMS). The disease is found in regions where the virus is rife, but its onset occurs weeks after the peak of the epidemic. The present study aims to uncover the innate and adaptive immune responses to reveal the aberrations that cause this syndrome. The later age at which MIS-C presents, compared to classical KD, could be due to its association with a novel virus. The future impact of the autoantibodies elicited by the infection also remains to be seen, even though the current episode is transient. 

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Ref link: https://www.news-medical.net/news/20200707/Research-sheds-light-on-mysterious-COVID-19-related-hyperinflammatory-shock-in-children.aspx