A retrospective single-center study was conducted to identify the change of blood routine laboratory parameters in Covid-19, which would be beneficial in COVID-19 diagnosis and prognosis. Information of 2648 patients aged above 18 was retrieved and divided into three groups i.e. COVID-19 patients treated in ICU, non-ICU COVID-19 patients, and a control group who never contracted COVID-19. Routine blood parameters like CBC, ferritin, prothrombin time, activated partial prothrombin time (aPTT), fibrinogen, CRP, procalcitonin (PCT), D-dimer and troponin were analyzed. Also, derived novel biomarkers like d − CL, d − CWL, d − CFL, d − CT were studied and compared with known biomarkers LYM, NLR, LCR, PLR, d-NLR.
There was a significant increase in CRP, D-Dimer, Ferritin, Fibrinogen, Procalcitonin, Neutrophils, ESR, and aPPT and a significant decrease in platelet count, WBC count, lymphocyte count and LCR in both ICU and non-ICU COVID-19 patients when compared with control. d-TI was constant in non ICU and control groups but elevated in ICU patients. Novel biomarkers like d-CWL and dCFL were the highest among COVID-19 patients and could effectively be used for COVID-19 diagnosis. Another set of novel biomarkers d-CT, d-CIT, and d-PPT was significantly high only in ICU patients and could effectively be used to distinguish between ICU and non-ICU patients.
Thus, relevant routine blood parameters and biomarkers can be beneficial for rapid diagnosis of COVID-19 and starting the initial treatment.
Source: International immunopharmacology
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