Biomarkers can Aid Preventing Clinical Deterioration of COVID-19 Patients

Biomarkers are the biological markers that are evaluated in the clinical scenario to act as an indicator of certain biological, pathogenic, or pharmacological processes. This particular knowledge was inculcated in a retrospective cohort study, to identify the association that might reside between biomarkers observed in COVID-19 exposed individuals with their clinical outcomes.

To identify the possible association, laboratory tests were conducted in a total of 299 COVID-19 patients, admitted to the medicinal service at GWUH to record the following biomarkers

  1. CRP

  2. D-dimer

  3. IL-6

  4. Ferritin

  5. LDH

Out of total enrolled patients, 200 patients were observed to possess biomarkers of notable interest. Elevated levels of these markers were associated with bleeding disorder and inflammation. The highest deaths occurred when the LDH level was greater than 1200 U/L and D-dimer level was more than 3g/mL. Therefore, it can be suggested that the detection and close monitoring of these biomarkers in the COVID-19 patients can provide clinicians hand on information regarding the identification of those patients that might be at risk of facing clinical deterioration in the time to come.

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Ref link: https://www.futuremedicine.com/doi/10.2217/bmm-2020-0309