Recent studies have shown that the immune response may last up to 4 months. An international study conducted by researchers from Germany, Italy, Sweden, China, and the USA aimed to determine the longevity of immune response against SARS-CoV-2. The researchers testes a cluster of patients from the Lombardy region, along with Swedish volunteers. The team detected the presence of elevated anti-receptor binding domain and anti-spike antibodies. The team found that levels of specific IgM and IgA declined after a month. Interestingly, specific IgG levels were stable for up to 6 months after infection.
The levels of anti-RBD and anti-S IgG antibodies started declining between 6-8 months. The decline in anti-S and anti-RBD IgA and IgM levels were noted 1-3 months after the infection. The antibody response existed in most COVID-19 patients as early as 2 weeks after symptom onset. Men had higher anti-RBD IgG antibody titers. Around 7% of patients who developed severe COVID-19 did not develop or had an extremely low level of antibodies after being infected. The team detected the presence of high levels of SARS-CoV-2 specific memory B and T-cells in the majority of patients 6-8 months after infection. This suggests long-term immunity and that development of immunity through vaccination might be possible.
To know more about origin, virology of COVID-19, Click here
To know more about emerging themes in COVID-19, Click here
To know more about how WhiteCoats can help you in your professional advancement, visit www.whitecoats.com
Want to set up an online consultation for your practice, Click here
Ref link: https://www.biorxiv.org/content/10.1101/2020.11.06.371617v1