Angiopoietin-2: A Crucial Determinant of COVID-19 Prognosis

A team of researchers from the USA and Sweden has recently demonstrated that increased levels of the proinflammatory cytokine, angiopoietin-2 (ANG2), is responsible for hypercoagulation observed in severe COVID-19 patients. In the current study, the scientists evaluated whether an elevated plasma level of ANG2 in critically ill COVID-19 patients can modulate the coagulation system by inhibiting thrombomodulin-mediated activation of protein C.

The study was conducted on 20 critically ill COVID-19 patients admitted to the ICU for more than 10 days. Overall, an elevated ANG2 level was observed in plasma samples of all critically ill COVID-19 patients. A significantly high ANG2 level was found to be associated with the risk of organ failure and death. Significantly elevated levels of platelet, D-dimer, and von Willebrand factor and significantly reduced levels of ADAMTS13 were observed in all COVID-19 patients. ANG2 was found to inversely correlate with the ADAMTS13 level. These observations indicate that the pro-coagulation process is significantly impaired in these patients and that ANG2 plays a crucial role in mediating hypercoagulation, which is a frequently observed symptom in critically ill COVID-19 patients.

The study findings demonstrate that an increased level of ANG2, a proinflammatory cytokine, in COVID-19 patients is associated with disease severity, hypercoagulation, and mortality. Given these observations, the scientists believe that therapeutic inhibition of ANG2 can be a potential approach for treating severe COVID-19 patients, as well as for alleviating cardiovascular complications associated with the disease.

To know more about origin, virology of COVID-19, Click here

To know more about emerging themes in COVID-19, Click here

To know more about how WhiteCoats can help you in your professional advancement, visit www.whitecoats.com

Want to set up an online consultation for your practice, Click here

Ref link: https://www.medrxiv.org/content/10.1101/2021.01.13.21249429v1

#Featured